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SR-717 demonstrates broad interspecies and interallelic specificity
AT 1 852 SR-717 demonstrates broad interspecies andCell penetrant Proteolysis Targeting Chimera (PROTAC) compound based on (+) JQ1 (Cat. No. 4499) conjugated to a von Hippel Lindau (VHL) ligand. Rationally designed based on a ternary complex crystal structure to improve selectivity for BRD4 degradation compared to MZ1 (Cat. No. 6154). Demonstrates profound and selective degradation of BRD4 in cells at 1 3 M, with negligible loss of BRD2 and BRD3. Product information CAS Number: 2098836 45 2 Molecular
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