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3-thiazol-2-yl)piperidine-4-carboxamide
Less active than the S-isomer
Sialyl-Lewis X binds to ELAM-1 and CD62 and has the ability to inhibits CD62-mediated neutrophil recruitment to sites of inflammation
Combination with Erlotinib HCl could down-modulate rapamycin-stimulated Akt activity and produces a synergistic effect on cell growth inhibition
Formula: C21H19NO3S
TAS-119 4028 3-thiazol-2-yl)piperidine-4-carboxamideTAS 119 is a potent, selective and orally active Aurora A inhibitor with an IC50 of 1. 0 nM. TAS 119 shows high selectivity for Aurora A over other protein kinases, including Aurora B (IC50 of 95 nM). TAS 119 has potent antitumor activites. Product information CAS Number: 1453099 83 6 Molecular Weight: 506. 36 Formula: C23H22Cl2FN5O3 Chemical Name: 1 (2,3 dichlorobenzoyl) 4 ({5 fluoro 6 [(5 methyl 1H pyrazol 3 yl)amino]pyridin 2 yl}methyl)piperidine 4