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and phosphorylated Smad3 in keloid fibroblasts
) significantly increases the ambulation of mice at 0
a novel inhibitor of the DNA repair enzyme DNA-dependent protein kinase (DNA-PK)
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CAS Number: 548470-11-7
Dinaciclib - CAS# 779353-01-4 Catalog No.:M10712-10 and phosphorylated Smad3 in keloidDinaciclib, also known as SCH727965, is a potent CDK inhibitor with potential antineoplastic activity. Dinaciclib selectively inhibits cyclin dependent kinases CDK1, CDK2, CDK5, and CDK9 activity in vitro with IC(50) values of 1, 1, 3, and 4 nmol L, respectively. Compared with flavopiridol, Dinaciclib exhibits superior activity with an improved therapeutic index. Dinaciclib induced regression of established solid tumors in a range of mouse models
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