Compound 56 Catalog No.:M22023-C Smiles: CC(CC(O)=O)CN

Smiles: CC(CC(O)=O)CN

Trofosfamide is an orally bioavailable oxazaphosphorine derivative with antineoplastic activity

low protein binding (88

and FLT3-D835Y are inhibited by BPR1J-097 Hydrochloride at a concentration as low as 10 nM

384(1):166-9

Compound 56 Catalog No.:M22023-C Smiles: CC(CC(O)=O)CNCompound 56, 4 [(3 Bromophenyl)amino] 6,7 diethoxyquinazoline, is a potent and specific inhibitor of the tyrosine kinase of the epidermal growth factor receptor (EGFR) showing an IC50 of 0. 006 nM. It competitively binds at the adenosine triphosphate (ATP) site of EGFR. Compound 56 is capable of inhibiting the phosphorylation of EGF dependent EGFR, suppressing the proliferation and clonogenicity of a wide panel of EGFR overexpressing human cancer