ZLJ-6 Size:Contact [email protected] for quotation InChi: InChI=1S/C27H36N2O4/c1-4-33-25-17-20(12-13-22(25)27(31)32)18-26(30)28-23(16-19(2)3)21-10-6-7-11-24(21)29-14-8-5-9-15-29/h6-7

InChi: InChI=1S/C27H36N2O4/c1-4-33-25-17-20(12-13-22(25)27(31)32)18-26(30)28-23(16-19(2)3)21-10-6-7-11-24(21)29-14-8-5-9-15-29/h6-7

InChiKey: PYFRREJCFXFNRR-UHFFFAOYSA-N

CAS Number: 586357-02-0

was isolated from an extract of Hypericum perforatum L

InChiKey: UEBIBJSWHIZNCA-BGPUAMRSSA-N

ZLJ-6 Size:Contact [email protected] for quotation InChi: InChI=1S/C27H36N2O4/c1-4-33-25-17-20(12-13-22(25)27(31)32)18-26(30)28-23(16-19(2)3)21-10-6-7-11-24(21)29-14-8-5-9-15-29/h6-7IC50: 0. 73, 0. 31, and 0. 99 M for COX 1, COX 2, and 5 LO, respectively ZLJ 6 is a dual inhibitor of COX and 5 lipoxygenase (5 LO). Cyclooxygenase (COX) is an enzyme that is responsible for formation of prostanoids, such as thromboxane and prostaglandins such as prostacyclin. 5 lipoxygenase (5 LO) is the major source of leukotrienes. In vitro: ZLJ 6 was identified as a potent inhibitor of cyclooxygenase in human whole blood. It also inhibited the