21-hydroxy Oligomycin A 8655 InChi: InChI=1S/C24H28N2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28/h3-11

InChi: InChI=1S/C24H28N2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28/h3-11

21-hydroxy Oligomycin A 8655 InChi: InChI=1S/C24H28N2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28/h3-1121 hydroxy Oligomycin A is an antibiotic which was first isolated from S. cyaneogriseus ssp. noncyanogenus . 21 hydroxy Oligomycin A functions as M inhibitor of the multidrug efflux pump P gp, and low nM inhibitors of K Ras PM localization . Cancer cell viability screening confirmed that 21 hydroxy Oligomycin A was cytotoxic to human colorectal carcinoma cells (IC50 > 3 M), and was inhibitor of the ABC transporter efflux pump P glyco protein (P gp).