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the CYP2E1 response is fairly equal among the different species
PubMed PMID: 24941674
Formula: C20H21N5
Ocular hypotensive efficacy
InChi: InChI=1S/C15H13F2NO4S/c1-9(19)10-3-5-13(18-23(2
Sobetirome - CAS# 211110-63-3 inib (S) the CYP2E1 response is fairlySobetirome, also known as GC 1 and QRX 431, is a hyroid hormone beta receptor agonist. Sobetirome inhibits proliferation but induces differentiation and TR beta mRNA expression in mouse and rat osteoblast like cells. Sobetirome selectively binds to and activates TRbeta over TRalpha and this receptor selectivity led to the hypothesis that sobetirome would lower cholesterol through activation of liver TRbeta without stimulating cardiac function through
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